摘要
目的 系统评价灸法辅助治疗勃起功能障碍(ED)的临床疗效与安全性,为灸法的临床应用提供循证医学证据.方法 计算机检索中国知网、万方、维普、SinoMed、PubMed、Embase和Cochrane数据库,搜索灸法辅助治疗ED的随机对照试验研究,检索时限从建库至2023年3月.由两位研究者独立进行文献筛选、资料提取和质量评价工作,采用RevMan 5.4软件进行Meta分析.结果 最终纳入13个研究,共1 175例研究对象.Meta分析结果显示:灸法辅助治疗ED与常规疗法相比,治疗总有效率提升(RR=1.23,95％CI:1.16～1.31,P＜0.000 01);国际勃起功能指数-5(IIEF-5)评分增加(MD=2.75,95％CI:2.38～3.12,P＜0.000 01);勃起硬度(EHS)评分增加,勃起硬度改善(MD=0.44,95％CI:0.30～0.58,P＜0.000 01);睾酮水平升高(MD=0.87,95％CI:0.66～1.08,P＜0.000 01);不良反应率显著降低(RR=0.41,95％CI:0.17～0.95,P=0.04).结论 灸法辅助常规疗法治疗ED,能有效提高治疗总有效率、IIEF-5评分、EHS评分及睾酮水平,降低不良反应率.
Abstract
Objective To systematically evaluate the clinical efficacy and safety of moxibustion assisted treatment of erectile dysfunction,and to provide evidence-based medical evidence for the clinical application of moxibustion.Methods Databases of CNKI,Wanfang,VIP,SinoMed,PubMed,Embase and Cochrane were searched by computer for the randomized controlled trail(RCT)studies on the assisted treatment of erectile dysfunction by moxibustion from the establishment of the database to March 2023.Literature screening,data extraction and quality evaluation were conducted independently by two researchers,and Meta-analysis was performed using RevMan 5.4 software.Results A total of 13 studies with a total of 1,175 subjects were included.The results of Meta-analysis showed that compared with conventional therapy,the total effective rate of moxibustion assisted treatment of ED was improved(RR=1.23,95％CI:1.16-1.31,P＜0.000,01);the international index of erectile function-5(IIEF-5)score was increased(MD=2.75,95％CI:2.38-3.12,P＜0.000,01);erectile hardness(EHS)score increased,erectile hardness improved(MD=0.44,95％CI:0.30-0.58,P＜0.000,01);testosterone levels increased(MD=0.87,95％CI:0.66-1.08,P＜0.000,01);the rate of adverse reactions was significantly decreased(RR=0.41,95％CI:0.17-0.95,P=0.04).Conclusions Moxibustion assisted conventional therapy in the treatment of ED can effectively improve the total effective rate,IIEF-5 score,EHS score and testosterone level,and reduce the rate of adverse reactions.
基金项目
河南省中医药科学研究专项课题(河南省中医管理局课题)(2018ZY2065)
河南中医药大学研究生科研创新类项目(2022KYCX046)
NETL
NSTL
万方数据