基于下丘脑-垂体-性腺轴分析淫羊藿苷对男性不育症的调控
Analysis of the regulation of icariin on male infertility based on hypothalamic-pituitary-gonadal axis
徐磊 1张培海 2徐子龙 1文泓志 1马紫阳2
作者信息
- 1. 成都中医药大学临床医学院,成都 610075;成都中医药大学附属医院代谢性疾病中医药调控四川省重点实验室,成都 610075
- 2. 成都中医药大学附属医院代谢性疾病中医药调控四川省重点实验室,成都 610075
- 折叠
摘要
近年来,不育症已成为当代男性的主要社会和健康问题之一.男性不育症病因十分复杂,目前针对男性不育症的治疗手段虽然很多,但费用相对昂贵,且疗效较差.淫羊藿作为男科常用的药物,长期以来一直在中药治疗男性不育症方面发挥着重要作用.淫羊藿苷是淫羊藿的主要化学成分,近年来,对淫羊藿苷的研究主要集中在治疗勃起功能障碍、抑制肿瘤细胞生长、控制高血压及冠心病等方面,在不育症方面的研究相对较少.因此,本文基于下丘脑-垂体-性腺轴理论,详细阐述了淫羊藿苷对睾丸前性病因、睾丸性病因及睾丸后性病因导致的不育症的调控机制,以期为临床治疗不育症提供一些思路.
Abstract
In recent years,infertility has become one of the major social and health problems of contemporary men.The etiology of male infertility is highly intricate.Despite the existence of numerous treatment modalities for male infertility,these treatments are relatively costly and yield suboptimal outcomes.The herb epimedium is a regular remedy in the field of andrology,playing a significant role in the treatment of male infertility with traditional Chinese medicine.The main chemical component of epimedium is known as icariin.In recent years,research on icariin has primarily focused on its potential in treating erectile dysfunction,inhibiting tumor cell growth,controlling hypertension and coronary heart disease,etc.However,there has been relatively limited research conducted on its effects on infertility.Therefore,based on the theory of hypothalamic-pituitary-gonadal axis,this paper thoroughly elucidates the mechanism of icariin on infertility through pretesticular,testicular,and post-testicular causes,aiming to offer insights for clinical management of infertility.
关键词
淫羊藿苷/男性不育症/雄激素/下丘脑-垂体-性腺轴Key words
Icariin/Male infertility/Androgen/Hypothalamic-pituitary-gonadal axis引用本文复制引用
基金项目
国家中医药局青年岐黄学者支持项目(HRS2020069)
四川省中医药局科学技术研究专项(2023MS454)
出版年
2024
NETL
NSTL
万方数据