Dynamic changes of tumor markers and lymphocyte-to-monocyte ratio in postoperative patients with stage Ⅱ A/Ⅱ B testicular seminoma before and after radiotherapy and their impact on short-term efficacy
Objective To analyze the dynamic changes of tumor markers,lymphocyte-to-monocyte ratio(LMR)before and after radiotherapy in patients with stage Ⅱ A/Ⅱ B testicular seminoma after surgery,and the relationship between them and the efficacy of radiotherapy.Methods The clinical data of postoperative patients with stage Ⅱ A/Ⅱ B testicular seminoma treated in Shanxi Provincial Cancer Hospital from July 2012 to July 2020 were retrospectively analyzed.According to the short-term efficacy status of radiotherapy,the patients were divided into effective group(n=16)and ineffective group(n=54).The baseline data of patients,tumor markers and LMR levels before and after radiotherapy were recorded and sorted out,and the relationship between tumor markers,LMR and short-term efficacy of radiotherapy was analyzed.Results Tumor diameter＞40 mm and testicular vascular invasion were the risk factors affecting the short-term effect of radiotherapy in patients with stage Ⅱ A/Ⅱ B testicular seminoma after surgery(P＜0.05).Serum lactate dehydrogenase(LDH)after radiotherapy in the effective group was lower than that before radiotherapy,and LMR was higher than that before radiotherapy(P＜0.05).The serum LDH of the ineffective group before and after radiotherapy was higher than that of the effective group,and the LMR value was lower than that of the effective group(P＜0.05).There was no statistically significant difference in the levels of serum alpha fetoprotein(AFP)and human chorionic gonadotropin(hCG)before and after radiotherapy between the two groups and intra-group comparison(P＞0.05).The serum LDH levels before and after radiotherapy were positively correlated with tumor diameter and testicular vascular infiltration(r＞0,P＜0.05).LMR level before and after radiotherapy was negatively correlated with tumor diameter and testicular vascular infiltration(r＜0,P＜0.05).The area under the curve of serum LDH level,LMR value before radiotherapy,and combined prediction of ineffective radiotherapy were all greater than 0.7,the value of combined prediction was relatively high.Conclusions The levels of serum LDH and LMR in patients with testicular seminoma after surgery are closely related to the short-term efficacy of radiotherapy.
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