Study on the relationship between the expression of selenium-binding protein 1 and selenoprotein F in prostate cancer tissues and clinical pathological characteristics and prognosis
Objective To study the relationship between the expression of selenium-binding protein 1(SELENBP1)and selenoprotein F(SELENOF)in prostate cancer(PC)tissues and clinical pathological characteristics and prognosis.Methods A total of 104 PC patients who were diagnosed and treated in Handan Central Hospital from January 2017 to January 2020 were selected as the research objects.The expression levels of SELENBP1 and SELENOF in cancer tissues and adjacent tissues of PC patients were detected,and the relationship between them and the clinical pathological characteristics and prognosis of PC patients were analyzed.The factors affecting of prognosis of PC patients were analyzed by multivariate Cox regression analysis.Results The positive rates of SELENBP1 and SELENOF in the cancer tissues of PC patients were lower than those in the adjacent tissues(P＜0.05).The positive rates of SELENBP1 and SELENOF in the cancer tissues of PC patients with different Gleason scores,TNM stages and preoperative prostate specific antigen(PSA)levels were compared and the differences were statistically significant(P＜0.05).The 3 years progression free survival rates of SELENBP1-negative patients and SELENOF-negative patients were lower than those of SELENBP1-positive patients and SELENOF-positive patients,respectively(P＜0.05).TNM stage 111,Gleason score＞7,SELENBP1-negative and SELENOF-negative were independent risk factors affecting the prognosis of PC patients(P＜0.05).Conclusions The expression of SELENBP1 and SELENOF in PC cancer tissues are decreased,and they are related to the poor clinicopathological features of PC patients,which can lead to the poor prognosis of PC patients.
Prostate cancerSelenium binding protein 1Selenoprotein FPathological characteristicsPrognosis
NETL
NSTL
万方数据
