前列腺癌组织中硒结合蛋白1、硒蛋白F表达与患者临床病理特征及预后的关系研究
Study on the relationship between the expression of selenium-binding protein 1 and selenoprotein F in prostate cancer tissues and clinical pathological characteristics and prognosis
张梦婷 1姚利敏 2李晓荣 1李岩 1李超 1贾天阳 1刘峥1
作者信息
- 1. 邯郸市中心医院肿瘤三科,河北邯郸 056001
- 2. 邯郸市妇幼保健院肿瘤科,河北邯郸 056000
- 折叠
摘要
目的 研究前列腺癌(PC)组织中硒结合蛋白1(SELENBP1)、硒蛋白F(SELENOF)表达与患者临床病理特征关系和预后的关系.方法 选取2017年1月至2020年1月邯郸市中心医院诊治的104例PC患者作为研究对象.检测PC患者癌组织和癌旁组织中SELENBP1、SELENOF表达水平,并分析两者与PC患者临床病理特征和预后的关系.采用多因素COX回归分析影响PC患者预后的因素.结果 PC患者癌组织中SELENBP1、SELENOF阳性率低于癌旁组织(P＜0.05).不同Gleason评分、TNM分期及术前前列腺特异性抗原(PSA)水平的PC患者癌组织中SELENBP1、SELENOF阳性率比较,差异具有统计学意义(P＜0.05)o SELENBP1阴性患者、SELENOF阴性患者3年无进展生存率分别低于SELENBP1阳性患者、SELENOF阳性患者(P＜0.05).TNM分期Ⅲ期、Gleason评分＞7分、SELENBP1阴性、SELENOF阴性是影响PC患者预后的独立危险因素(P＜0.05).结论 PC患者癌组织中SELENBP1、SELENOF表达降低,且两者与PC患者不良临床病理特征相关,可导致PC患者不良预后.
Abstract
Objective To study the relationship between the expression of selenium-binding protein 1(SELENBP1)and selenoprotein F(SELENOF)in prostate cancer(PC)tissues and clinical pathological characteristics and prognosis.Methods A total of 104 PC patients who were diagnosed and treated in Handan Central Hospital from January 2017 to January 2020 were selected as the research objects.The expression levels of SELENBP1 and SELENOF in cancer tissues and adjacent tissues of PC patients were detected,and the relationship between them and the clinical pathological characteristics and prognosis of PC patients were analyzed.The factors affecting of prognosis of PC patients were analyzed by multivariate Cox regression analysis.Results The positive rates of SELENBP1 and SELENOF in the cancer tissues of PC patients were lower than those in the adjacent tissues(P＜0.05).The positive rates of SELENBP1 and SELENOF in the cancer tissues of PC patients with different Gleason scores,TNM stages and preoperative prostate specific antigen(PSA)levels were compared and the differences were statistically significant(P＜0.05).The 3 years progression free survival rates of SELENBP1-negative patients and SELENOF-negative patients were lower than those of SELENBP1-positive patients and SELENOF-positive patients,respectively(P＜0.05).TNM stage 111,Gleason score＞7,SELENBP1-negative and SELENOF-negative were independent risk factors affecting the prognosis of PC patients(P＜0.05).Conclusions The expression of SELENBP1 and SELENOF in PC cancer tissues are decreased,and they are related to the poor clinicopathological features of PC patients,which can lead to the poor prognosis of PC patients.
关键词
前列腺癌/硒结合蛋白1/硒蛋白F/病理特征/预后Key words
Prostate cancer/Selenium binding protein 1/Selenoprotein F/Pathological characteristics/Prognosis引用本文复制引用
基金项目
河北省医学科学研究重点课题(20170444)
出版年
2024
NETL
NSTL
万方数据