Relationship between pregnancy-associated plasma protein-A,non-esterified fatty acids and angiotensin levels and gestational hypertension
Objective To analyze the relationship of levels of pregnancy-associated plasma protein-A(PAPP-A),non-esterified fatty acids(NEFA)and angiotensin(AGT)with gestational hypertension.Methods A total of 98 patients with gestational hypertension who were treated in the Obstetrics Department of Cangzhou City People's Hospital from December 2021 to December 2022 were selected as the observation group and were divided into mild,moderate,and severe groups according to the severity of the condition.Another 50 pregnant women with normal prenatal check-ups at the same hospital during the same period were selected as the control group.The serum levels of PAPP-A,NEFA,and AGT were measured at 12-14 weeks of pregnancy in both groups.The serum levels of PAPP-A,NEFA,and AGT were compared between the observation and control groups and among different subgroups within the observation group.Pearson correlation analysis was used to examine the correlations between serum levels of PAPP-A,NEFA,and AGT.Logistic regression analysis was used to identify the independent factors related to adverse pregnancy outcomes in patients with gestational hypertension.Results The levels of serum PAPP-A,NEFA and AGT in observation group were higher than those in control group(P＜0.05).Serum PAPP-A,NEFA and AGT levels in mild group,moderate group and severe group were increased successively(P＜0.05).The group with adverse pregnancy outcomes had higher proportions of adverse obstetric history and family history of hypertension,as well as higher serum levels of PAPP-A,NEFA,and AGT compared to the normal group(P＜0.05).Pearson correlation analysis showed that there was a positive correlation among serum PAPP-A,NEFA and AGT levels in patients with gestational hypertension(P＜0.05).Logistic multivariate regression analysis revealed that a history of adverse obstetric outcomes and serum levels of PAPP-A,NEFA,and AGT were independent risk factors for adverse pregnancy outcomes in gestational hypertension(P＜0.05).Conclusions Serum levels of PAPP-A,NEFA and AGT during pregnancy are closely related to the occurrence and severity of gestational hypertension,and are risk factors for adverse pregnancy outcomes.
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