Clinical efficacy of Shenling Baizhu Powder on treating osteoporosis in patients with spleen deficiency type human immunodeficiency virus infection
Objective To observe the clinical effect of Shenling Baizhu Powder on treating osteoporosis in patients with spleen deficiency type human immunodeficiency virus(HIV)infection.Methods A total of 80 patients with HIV infected osteoporosis and spleen deficiency treated in Infection Department of Guiyang Public Health Treatment Center were randomly divided into control group(given alendronate sodium,n=40)and experimental group(given alendronate sodium+Shenling Baizhu Powder,n=40).Clinical efficacy,traditional Chinese medicine(TCM)syndrome score,bone mineral density(BMD),bone metabolism indexes[parathyroid hormone(PTH),osteocalcin(OC),alkaline phosphatase(ALP),bone specific alkaline phosphatase(BALP)],resting and active visual analogue scale(VAS),and Klotho-fibroblast growth factor 23(FGF23)were analyzed.Results The total effective rate of the experimental group was higher than that of the control group(P＜0.05).After 4 weeks and 16 weeks of treatment,TCM syndrome scores of the experimental group were lower than those of the control group(P＜0.05).After 16 weeks of treatment,the BMD of L1-4,Ward triangle,femoral neck and total hip in the experimental group were higher than those in the control group(P＜0.05).After 4 and 16 weeks of treatment,the level of OC in the experimental group were higher than those in the control group,and the levels of ALP,BALP,PTH,Klotho protein and FGF23 were lower than those in the control group(P＜0.05).After 4 and 16 weeks of treatment,the scores of resting VAS and active VAS in the experimental group were lower than those in the control group(P＜0.05).Conclusions Shenling Baizhu Powder is effective in treating osteoporosis in patients with spleen deficiency type HIV.It can improve the BMD and bone metabolism condition,and reduce the degree of pain,which may be related to the inhibition of Klotho-FGF23 axis.
Shenling Baizhu PowderSpleen deficiency typeHuman immunodeficiency virus infectionOsteoporosisBone metabolismBone density
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