Effects of triptorelin on the efficacy and secondary sexual characteristics of girls with idiopathic central precocious puberty
Objective To investigate the efficacy of treatment with triptorelin in girls with idiopathic central precocious puberty and the effects on secondary sexual characteristics.Methods A total of 78 cases of idiopathic central precocious puberty girls diagnosed and treated in the Department of Pediatric,Zunhua People's Hospital from January 2021 to January 2022 were selected as the study objects,and were divided into the observation group and the control group according to the randomized numerical table method,with 39 cases in each group.In the control group,only basic interventions such as dietary adjustments were used,and in the observation group,treatment with triptorelin was used on the basis of the control group.The treatment effects,indicators of the development of secondary sexual characteristics(uterine volume,ovarian volume and breast size),growth indicators[height,weight and bone age/actual age(BA/CA)],sex hormone levels[follicle stimulating hormone(FSH),estradiol(E2),and luteinizing hormone(LH)],and drug safety were compared between the two groups.Results The total effective rate of the treatment in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＞0.05).Uterine volume,ovarian volume and breast size of the observation group were significantly smaller than those of the control group after 12 months of treatment,and the differences were statistically significant(P＜0.05).Weight,height and BA/CA levels of the observation group were significantly higher than those of the control group after 12 months of treatment,and the differences were statistically significant(P＜0.05).FSH,LH and E2 levels in the observation group were significantly lower than those in the control group after 12 months of treatment,and the differences were statistically significant(P＜0.05).Only 2 cases of minor rash reaction occurred in the observation group,and the drug safety is good.Conclusions The use of triptorelin in the treatment of girls with idiopathic central precocious puberty has good clinical effect.It can significantly suppress the levels of sex hormones,improve the indicators of the development of secondary sexual characteristics and growth indicators,and have a good safety profile.
TriptorelinGirlIdiopathic central precocious pubertyEfficacySecondary sexual characteristics
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