Clinical value of precursor of prostate-specific antigen and prostate health index related parameters in diagnosing patients with prostate cancer in gray area of serum total prostate-specific antigen
Objective To explore the clinical value of precursor of prostate-specific antigen(p2PSA)and prostate health index(PHI)related parameters in diagnosing patients with prostate cancer(PCa)in gray area of serum total prostate-specific antigen(tPSA).Methods A total of 286 patients with prostate lesions treated in Nanxun District People's Hospital between January 2019 and January 2023 were enrolled as the research objects.According to pathological results,they were divided into PCa group(n=78)and benign prostatic lesion group(n=208).After admission,all the patients underwent contrast-enhanced magnetic resonance imaging(MRI)examination of prostate.The levels of serum tPSA,free prostate-specific antigen(fPSA)and p2PSA were detected,the parameters of％fPSA,％p2PSA and PHI were calculated.The diagnostic value of score of prostate imaging-reporting and data system version 2(PI-DADS)in MRI,serum p2PSA,％p2PSA,PHI respective and combined detection for PCa were analyzed by receiver operating characteristic(ROC)curves,and the evaluation value of serum p2PSA,％fPSA,％p2PSA,PHI,MRI PI-DADS score respective and combined detection for the risk of Gleason score were analyzed.Results The MRI PI-DADS score,levels of p2PSA,％p2PSA and PHI in PCa group were higher than those in benign prostatic lesion group(P＜0.05).The area under curve(AUC),sensitivity and specificity of MRI PI-DADS score combined with serum p2PSA,％p2PSA and PHI in the diagnosis of PCa were 0.961,83.62％and 90.66％respectively,and the diagnostic efficiency of combined detection was greater than that of single index(P＜0.05).There were 29 cases with Gleason score ≥7 points and 49 cases with Gleason score ≤6 points.The MRI PI-DADS score,levels of serum p2PSA,％p2PSA and PHI in the Gleason score ≥7 point group were higher than those in the Gleason score≤6 point group,while its％fPSA was lower than that in the Gleason score ≤6 point group(P＜0.05).The AUC,sensitivity and specificity of MRI PI-DADS score combined with p2PSA,％fPSA,％p2PSA and PHI for evaluating the risk of Gleason score were 0.928,89.53％,and 81.24％,respectively.The evaluation efficiency of combined detection was greater than that of single index(P＜0.05).Conclusions p2PSA and PHI related parameters can be applied in the early diagnosis of PCa,and further improve the diagnostic effect of advanced PCa.
Prostate cancerProstate health indexPrecursor of prostate-specific antigenGleason score
万方数据
维普
