Research progress on mitophagy mediated by adenosine monophosphate activated protein kinase-mammalian target of rapamycin pathway in male reproduction
Mitophagy represents the process by which cells selectively degrade damaged or surplus mitochondria through the mechanism of autophagy.In recent years,there is evidence indicating that mitophagy plays a critical role in male reproduction by clearing abnormal mitochondria,thereby reducing oxidative stress and maintaining the energy homeostasis of reproductive cells.As a classical pathway that regulates cellular growth and metabolism,the adenosine monophosphate activated protein kinase(AMPK)-mammalian target of rapamycin(mTOR)pathway generates autophagic machinery and regulates mitochondrial proteins,facilitating the sequestration of mitochondria within autophagosomes,thereby mediating mitophagy.This article elucidates the mechanisms by which the AMPK-mTOR pathway modulates mitophagy at both central and gonadal levels within the hypothalamic-pituitary-gonadal axis,aiming to provide novel insights and perspectives for ameliorating the quality of spermatozoa.
Adenosine monophosphate activated protein kinaseMammalian target of rapamycinMale reproductionMitophagy
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