Mitophagy represents the process by which cells selectively degrade damaged or surplus mitochondria through the mechanism of autophagy.In recent years,there is evidence indicating that mitophagy plays a critical role in male reproduction by clearing abnormal mitochondria,thereby reducing oxidative stress and maintaining the energy homeostasis of reproductive cells.As a classical pathway that regulates cellular growth and metabolism,the adenosine monophosphate activated protein kinase(AMPK)-mammalian target of rapamycin(mTOR)pathway generates autophagic machinery and regulates mitochondrial proteins,facilitating the sequestration of mitochondria within autophagosomes,thereby mediating mitophagy.This article elucidates the mechanisms by which the AMPK-mTOR pathway modulates mitophagy at both central and gonadal levels within the hypothalamic-pituitary-gonadal axis,aiming to provide novel insights and perspectives for ameliorating the quality of spermatozoa.
Adenosine monophosphate activated protein kinaseMammalian target of rapamycinMale reproductionMitophagy
维普
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