Analysis of risk factors and genotyping of human papilloma virus infection in men of childbearing age
Objective To identify the risk factors of human papilloma virus(HPV)infection in the reproductive system in men of childbearing age,and to analyze the genotypes of infection in different parts.Methods A total of 1,205 men of childbearing age who were diagnosed and treated in the Department of Urology,Shanghai Changning Maternity and Infant Health Hospital from January to December 2022 were selected as the research subjects.Polymerase chain reaction(PCR)and reverse hybridization were used to detect HPV-DNA in the samples,and the detection rate of HPV in the exfoliated cell of external genitalia samples and semen samples was compared.Logistic regression was used to analyze the risk factors of HPV infection.Results A total of 53 HPV positive samples were detected in 1,205 male exfoliated cell of external genitalia samples,and the positive detection rate was 4.40％.A total of 37 semen samples were HPV positive,and the positive detection rate was 3.07％.The difference of HPV positive detection rate between the two kinds of samples was statistically significant(P＜0.05).In low-risk genotype,there was a statistically significant difference in the detection rate of single infection and multiple infections between the two kinds of samples(P＜0.05);but in high-risk and mixed genotype,there was no statistically significant difference in the detection rate of single infection and multiple infections between the two kinds of samples(P＞0.05).Age at first sexual intercourse(OR:2.317,95％CI:1.612-3.305),number of sexual partners(OR:4.329,95％CI:1.326-9.491),whether the sexual partner was infected with HPV(OR:20.442,95％CI:4.506-48.383),frequency of sexual intercourse per week(OR:3.155,95％CI:2.185-5.215),balanitis prepuce(OR:18.231,95％CI:4.922-20.344),long prepuce or phimosis(OR:5.281,95％CI:1.073-9.431)were all risk factors for HPV infection in men of childbearing age(P＜0.05).Conclusions Risk factors for HPV infection in men of childbearing age are closely related to sexual behavior patterns and reproductive health status.There are different genotypes characteristics of HPV infection in exfoliated cell of external genitalia and semen.
万方数据
维普
