Effect of improving vaginal microecology on cervical duct adhesion in patients with high-grade cervical squamous intraepithelial lesions after loop electrosurgical excision procedure
Objective To investigate the effect of improving vaginal microecology on cervical duct adhesion in patients with high-grade cervical squamous intraepithelial lesions(HSIL)after loop electrosurgical excision procedure(LEEP).Methods A total of 210 patients with HSIL underwent LEEP admitted to People's Hospital of Hengshui from November 2021 to January 2023 were selected as the study objects,and were divided into control group and experimental group according to random number table method,with 105 cases in each group.After operation,the control group was treated with estriol ointment,and the experimental group was treated with estriol ointment combined with lactobacillus live capsule for 10 days.The incidence of postoperative cervical adhesion,vaginal microecology and functional enzyme activity of vaginal secretions before and after surgery were compared between the two groups.Results The incidence of cervical adhesion in experimental group was lower than that in control group,the difference was statistically significant(P＜0.05).At 2 weeks after surgery,pH 3.8-4.5,vaginal flora density Ⅰ-Ⅱ and normal incidence of vaginal microecology in experimental groups were higher than those in control group,with statistical significances(P＜0.05).At 6 weeks after surgery,the positive rate of sialidase(SNA)activity in experimental group was lower than that in control group,and the difference was statistically significant(P＜0.05).At 12 weeks after surgery,the positive rates of hydrogen peroxide(H2O2),leucocyte esterase(LE)and SNA activity in experimental groups were all lower than those in control group,and the differences were statistically significant(P＜0.05).Conclusions Clinical treatment of Lactobacillus therapy in patients with HSIL after LEEP can reduce the incidence of postoperative cervical adhesions,improve vaginal microecology and regulate the functional enzyme activity of vaginal secretions.
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