Correlation analysis between anti-Müllerian hormone and sex hormones,glucose-lipid metabolism in patients with polycystic ovary syndrome at different age groups
Objective To analyze the correlation between anti-Müllerian hormone(AMH)and sex hormones,glucose-lipid metabolism in patients with polycystic ovary syndrome(PCOS)at different age groups.Methods The clinical data of 150 patients with PCOS treated in Qinzhou Second People's Hospital from January 2022 to May 2023 were retrospectively analyzed and included as PCOS group(n=150).According to PCOS patients'ages,they were divided into group A(＜25 years old),group B(25 ≤ Age＜30 years old)and group C(30 ≤ Age＜35 years old),with 50 cases in each group.A total of 92 healthy women underwent health examination in the same hospital during the same period were enrolled as control group.AMH levels in PCOS group and control group were compared,as well as in different age groups of PCOS group.The levels of sex hormone[luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E2),testosterone(T)],glucose-lipid metabolism indexes[fasting plasma glucose(FPG),fasting insulin(FINS),insulin resistance index(HOMA-IR),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)]and thyroid hormones[serum free triiothyrogenine(FT3),free thyroxine(FT4),hypersensitive thyroxine(TSH)]in different age groups of PCOS group were compared.The correlation between AMH and sex hormones,glucose-lipid metabolism was analyzed by Spearman analysis.Results AMH level in PCOS group was higher than that in control group(P＜0.05).With age,FSH level was increased,while AHM and LH levels were decreased(P＜0.05).There was no significant difference in thyroid function among patients at different age groups of PCOS group(P＞0.05).With age,LDL-C and HOMA-IR levels were increased,while HDL-C level was decreased(P＜0.05).AMH level was negatively correlated with FSH,HDL-C and HOMA-IR levels(r=-0.322,-0.490,-0.184;P＜0.05),while positively correlated with LH and HDL-C levels(r=0.877,0.222;P＜0.05).Conclusions Compared with normal people,AMH level is higher in PCOS patients,and it decreases with age.AMH level is correlated with FSH,HOMA-IR,LH and HDL-C levels.
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