Study of vaginal microbiota and expression of hypersensitive C-reactive protein and transforming growth factor-β1 in patients with high-risk human papilloma virus infected cervical lesions
Objective To analyze vaginal microbiota and the expression of hypersensitive C-reactive protein(hs-CRP)and transforming growth factor-β1(TGF-β1)in patients with high-risk human papilloma virus(HR-HPV)infected cervical lesions.Methods A total of 112 patients with cervical lesions who were treated in Tangshan Maternal and Child Health Hospital from January 2021 to March 2023 were collected as the study subjects.According to the pathological diagnosis,the patients were separated into a cervical intraepithelial neoplasia(CIN)group(n=60)and a cervical cancer group(n=52).A total of 50 patients with benign cervical lesions without human papilloma virus(HPV)infection admitted to hospital during the same period were selected as the control group.Vaginal microbiota,vaginitis detection condition,serum hs-CRP and TGF-β1 expression levels were compared among the three groups.Multivariate Logistic regression was applied to analyze the influencing factors of cervical lesions caused by HR-HPV infection.Results The pH positive rate and H2 O2 positive rate of the cervical cancer group were both higher than those of the CIN group and the control group,and the normal rate of bacterial population density,normal rate of microbial diversity,and normal rate of dominant bacteria were all lower than those of the CIN group and the control group,the pH positive rate and H2 O2 positive rate in CIN group were both higher than those in control group,and normal rate of bacterial population density,normal rate of microbial diversity,and normal rate of dominant bacteria were all lower than those in control group(P＜0.05).The detection rates of bacteriad vaginosis(BV)and vulvovaginal candidiasis(VVC)were both higher in the cervical cancer group than in the CIN group and the control group,the detection rates of BV and VVC in the CIN group were both higher than those in the control group(P＜0.05).The serum levels of hs-CRP and TGF-β1 in the cervical cancer group were both higher than those in the CIN group and the control group,and serum hs-CRP and TGF-β1 levels in the CIN group were both higher than in the control group(P＜0.05).PH value,abnormal dominant bacteria,BV,hs-CRP,and TGF-β1 were the influencing factors of HR-HPV infection in cervical lesions(P＜0.05).Conclusions Patients with HR-HPV infected cervical lesions are significantly correlated with vaginal microbiota imbalance,BV occurrence,serum hs-CRP and TGF-β1 expression.
万方数据
维普
