Analysis of vaginal microecology condition and influencing factors in patients with cervical intraepithelial neoplasia caused by high-risk human papilloma virus infection
Objective To investigate the vaginal microecology condition and influencing factors in patients with cervical intraepithelial neoplasia(CIN)caused by high-risk human papilloma virus(HR-HPV)infection.Methods A total of 296 patients with CIN admitted to Shijiazhuang Maternal and Child Health Hospital from May 2018 to June 2019 were selected as the research objects.According to the results of HR-HPV test,they were divided into infection group(n=260)and non-infection group(n=36).The vaginal microecology condition of the two groups was compared,and the influencing factors of HR-HPV infection in CIN patients were analyzed by Logistic regression.Results The incidence of HR-HPV infection was 87.84％.The incidence of first sexual life age＜18 years old,number of sexual partners≥3,sialidase,catalase,proline aminopeptidase,bacterial vaginitis(BV),mycoplasma positive rate,vaginal cleanliness and abnormal rate of flora diversity in the infection group were higher than those in the non-infection group(P＜0.05).The age of first sexual life＜18 years old,the number of sexual partners ≥3,sialidase,catalase,proline aminopeptidase,BV,mycoplasma positive,vaginal cleanliness and abnormal flora diversity were the influencing factors of HR-HPV infection in CIN patients(OR＞1,P＜0.05).Conclusions HR-HPV infection is closely related to the vaginal microecology condition of CIN patients.Abnormal vaginal microecology and flora diversity can increase the risk of HR-HPV infection.
High-risk human papilloma virusCervical intraepithelial neoplasiaVaginal microecology
万方数据
维普
