Clinical analysis of skin immune function changes in syphilis patients with human immunodeficiency virus coinfection
Objective To analyze the changes of skin immune function in syphilis patients with human immunodeficiency virus(HIV)infection.Methods A total of 101 syphilis patients admitted to Hebei Institute of Dermatology from January 2021 to December 2022 were selected as the study objects and divided into HIV-positive group(n=66)and HIV-negative group(n=35)according to whether they were co-infected with HIV.The baseline data,skin tissue epidermal layer index,immune function index and so on were compared between the two groups.Results There were no significant differences in gender,age and hemoglobin(Hb)level between the two groups(P＞0.05).There were significant differences in transmission route and marital status between the two groups,and the level of C-reactive protein(CRP)in HIV-positive group was lower than that in HIV-negative group(P＜0.05).In the epidermal layer of skin tissue,the density of sensory nerve endings in the HIV-positive group was significantly higher than that in the HIV-negative group,and the levels of β-endorphin and dynorphin A were significantly lower than those in the HIV-negative group(P＜0.05).In terms of immune function indexes,CD4+cell count,CD4+/CD8+ratio and CD3+cell count in HIV-positive group were lower than those in HIV-negative group,and CD8+cell count was higher than that in HIV-negative group(P＜0.05).The helper T cell(Th)1 and Th1/Th2 ratio in HIV-positive group were lower than those in HIV-negative group,and the Th2 ratio was higher than that in the HIV-negative group(P＜0.05).The level of interleukin-2(IL-2)in HIV-positive group was lower than that in the HIV-negative group,and the IL-10 level was higher than that in the HIV-negative group(P＜0.05).Conclusions The skin immune function of syphilis patients with HIV infection showed significant changes,showing increased density of sensory nerve endings,decreased levels of β-endorphin and dynorphin A,and abnormal indicators of immune function.In addition,there were significant differences in Th1,Th2,Th1/Th2 ratios in peripheral blood and serum levels of IL-2 and IL-10.It is suggested that HIV infection may have an effect on the immune system of syphilis patients.
SyphilisHuman immunodeficiency virusSkin immune functionDensity of sensory nerve endingsImmune function index
万方数据
维普
