Research progress of autophagy mediated male infertility based on spermatogenesis
Male infertility is a kind of disease that the normal process of sperm production and transportation was destroyed under the action of internal and external factors,resulting in low fertility.Sperm are produced by spermatogenic cells through the process of spermatogenesis.Autophagy is an important intracellular clearance mechanism.Through degrading damaged or senescent organelles or proteins by autophagic lysosomes,cell component renewal and maintain cell homeostasis were achieved.Stable autophagy exists in spermatogenic cells and somatic cells in testis,which is important for maintaining their physiological function.When the cells are stimulated by pathogenic factors,the autophagy level is abnormal,structural damage or functional abnormalities occur,and even death occurs,which interferes with the normal spermatogenesis process and affects male fertility.In this paper,autophagy-related research on spermatogenic cells,somatic cells and common sterility factors based on spermatogenesis process,were reviewed,hoping to provide new ideas for the pathogenesis and treatment of male infertility.
万方数据
维普
