The incidence of infertility is relatively high globally,with the male factors accounting for 30％-50％.Oxidative stress is considered one of the main causes of male infertility.Excessive production of reactive oxygen species and/or inadequate antioxidant defense ability in vivo can lead to pathological processes such as lipid peroxidation,DNA damage,and increased cell apoptosis in male germ cells and sperm,ultimately resulting in male reproductive problems.This article aims to elucidate the mechanism of oxidative stress,the pathological role of oxidative stress in male reproduction,biomarkers of oxidative stress in semen,and treatment for oxidative stress-related male infertility.
关键词
男性不育/氧化应激/脂质过氧化/DNA损伤/凋亡/活性氧
Key words
Male infertility/Oxidative stress/Lipid peroxidation/DNA damage/Apoptosis/Reactive oxygen species
维普
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