Curative effect analysis of individualized treatment based on UPOINT(S)phenotype classification system in chronic prostatitis/chronic pelvic pain syndrome combined with sexual dysfunction patients
Curative effect analysis of individualized treatment based on UPOINT(S)phenotype classification system in chronic prostatitis/chronic pelvic pain syndrome combined with sexual dysfunction patients
Objective To verify the clinical efficacy of chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)patients combined with sexual dysfunction(SD)represented by erectile dysfunction(ED)and/or premature ejaculation(PE)receiving clinical symptom-oriented standardized diagnosis and individualized treatment based on the UPOINT(S)phenotype classification system,and to provide a basis for selecting clinical treatment options.Methods A total of 160 CP/CPPS patients combined with SD represented by ED and/or PE in outpatient clinics of the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army from January 2018 to December 2021 were selected as study objects and randomly divided into a control group for conventional drug therapy(n=53),a traditional group with guided treatment based on the traditional UPOINT phenotype classification system(n=49),an improvement group with guided treatment based on the improved UPOINT(S)phenotype classification system(n=58).According to the changes in National Institutes of Health chronic prostatitis symptom index(NIH-CPSI),maximum urinary flow rate(Qmax),visual analogue scale(VAS),international index of erectile function-5(IIEF-5),Chinese index of sexual function for premature ejaculation(C-ISFPE),and expressed prostatic secretion white blood cell count(EPS-WBC)before and after treatment,the differences in clinical efficacy between the three groups were evaluated.Results There was no statistical difference in clinical data in three groups of treatment(P＞0.05).After treatment,the traditional group and the improvement group improved in all indicators compared with the control group,with statistical differences(P＜0.05);compared with the traditional group,the improvement group improved more significantly in treatment of ED(IIEF-5 score:22.0±1.2 vs.19.8±2.0,P=0.006)and PE(C-ISFPE score:25.5±1.8 vs.19.5±2.2,P=0.005),with statistically significant differences(P＜0.05).Conclusions Individualized treatment based on the UPOINT(S)phenotype classification system can significantly improve the abnormal sexual function status of CP/CPPS patients combined with SD,and has better efficacy compared with conventional treatment and treatment based on traditional UPOINT phenotype classification system.
维普
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