A study on the correlation between abnormal levels of triglycerides and the morbidity risk of non-obstructive azoospermia
Objective To investigate the corr-elation between abnormal levels of triglycerides(TG)and the morbidity risk of non-obstructive azoospermia(NOA).Methods The clinical levels of data of 119 NOA patients admitted to Qinhuangdao First Hospital from September 2020 to September 2023 were retrospectively analyzed and set as the research group,and the physical examination data of 119 healthy men who had given birth during the same period were selected as the control group.According to the levels of TG,the two groups were divided into TG abnormal group(n=138)and TG normal group(n=100).The association between TG levels and the morbidity risk of NOA was analyzed by restricted cubic spline(RCS).Logistic regression was conducted to analyze the influencing factors of NOA morbidity.Pearson method was conducted to analyze the correlation between TG and sexual hormones.Results The incidence of NOA in TG abnormal group was 57.25％(79/138),which was higher than 40.00％(40/100)in TG normal group,with a statistically significant difference(x2=6.899,P=0.009).The proportion of body mass index(BMI)≥28.0 kg/m2 in TG abnormal group was higher than that in TG normal group,and the level of testosterone was lower than that in TG normal group,with statistical significances(P＜0.05).Logistic regression analysis showed that abnormally elevated TG was associated with the risk of NOA[OR(95％CI):2.008(1.190-3.389),P=2.008].After adjusting for confounding factors(BMI and testosterone),abnormal elevation of TG was still associated with the risk of NOA[OR(95％CI):1.780(1.025-3.089),P=0.040].The RCS analysis showed a non-linear dose-response relationship between TG levels and the morbidity risk of NOA.When TG levels abnormally increased,the morbidity risk of NOA also increased.Pearson correlation analysis showed that TG was negatively correlated with testosterone(r=-0.139,P=0.032)and positively correlated with follicle stimulating hormone(FSH)(r=0.179,P=0.006).Conclusions Abnormal TG levels are associated with the occurrence of NOA.The higher the TG levels,the higher the morbidity risk of NOA.Clinical considerations can be made to control TG levels to prevent the occurrence of NOA.
万方数据
维普
