Causal relationship between beverage habits and male infertility:a Mendelian randomization study
Objective To investigate the causal relationship between tea intake or coffee intake and male infertility by Mendelian randomization(MR)study.Methods Based on the published genome-wide association study(GWAS)of tea intake or coffee intake and male infertility in the Europe population,genetic loci associated with tea intake or coffee intake was used as instrumental variables,and inverse variance weighting(IVW)was used as the main analysis method to conduct a two-sample MR analysis.Heterogeneity test,pleiotropy test and leave-one-out method were used for sensitivity analysis to evaluate the robustness of the analysis results.Results The IVW method showed no correlation between tea intake or coffee intake and male infertility(tea intake:OR=0.75,P=0.71＞0.05;coffee intake:OR=1.46,P=0.51＞0.05).Sensitivity analysis results were robust,with no evidence of horizontal pleiotropy or heterogeneity among single nucleotide polymorphism(SNP).Conclusion Tea intake or coffee intake does not increase the risk of male infertility.
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