Study progress in genetic causes and management strategies for premature ovarian insufficiency
Premature ovarian insufficiency(POI),characterized by reduced ovarian function,early aging,and hormonal imbalance in women before the age of 40,is one of the leading causes of female infertility.The specific etiology of POI is not yet fully understood,and clinically it is considered to include genetic,autoimmune,infectious,or iatrogenic factors.Among them,genetic causes account for 20％to 25％of all cases.Identifying the precise pathogenic genes for POI has always been challenging,and the pathogenic mechanisms of the known genes have not been fully elucidated.Understanding the underlying molecular mechanisms is crucial for the prevention and early diagnosis of POI.Therefore,this article provides a review of the study progress in the current known pathogenic genes and the therapeutic methods targeting the pathogenic genes.
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