The predictive value of serum anti-Müllerian hormone and estradiol on ovarian reserve function,post-treatment ovarian response and pregnancy outcome in infertile patients
Objective To explore the predictive value of serum anti-Müllerian hormone(AMH)and estradiol(E2)on ovarian reserve function,ovarian function and pregnancy outcome after dehydroepiandrosterone(DHEA)treatment.Methods A total of 108 cases of infertility patients admitted in Suzhou Ninth People's Hospital from July 2020 to June 2022 were selected as study objects,and all the patients were treated with DHEA.The serum AMH and E2 levels were compared between patients with decreased ovarian reserve functions and low ovarian response and normal patients.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum AMH and E2 on decreased ovarian reserve function and serum AMH on low ovarian response.The clinical data of patients with different pregnant outcomes was compared.Results Serum AMH of patients with reduced ovarian reserve function were significantly lower than those of patients with normal ovarian reserve function(P＜0.05),and their E2 were higher than those of normal patients(P＜0.05).The area under the curve(AUC)of ROC curve of serum AMH and E2 in predicting decreased ovarian reserve function were 0.805 and 0.775,respectively(P＜0.05).The serum AMH of patients with low ovarian response was lower than that of patients with normal ovarian response(P＜0.05).The AUC of the ROC curve of serum AMH in predicting low ovarian response was 0.864(P＜0.05).Comparison of the age,body mass index,infertility duration,infertility types,AMH,E2 and testosterone between clinical pregnant and non-pregnant patients showed no statistical significance(P＞0.05).Conclusions Serum AMH and E2 levels have certain predictive value in the decreased reproductive reserve function of infertility patients,and serum AMH has certain value in predicting low ovarian response.However,serum AMH and E2 have no significant value in predicting pregnancy outcomes.
InfertilityAnti-Müllerian hormoneEstradiolDehydroepiandrosteroneOvarian function
万方数据
维普
