Effect of different ovulation induction protocols on pregnancy outcomes of patients with poor ovarian response undergoing in vitro fertilization-embryo transfer
Objective To explore the pregnancy outcomes of different ovulation induction protocols in patients with poor ovarian response(POR)undergoing in vitro fertilization-embryo transfer(IVF-ET).Methods The clinical data of 214 patients with POR who received in vitro fertilization/intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET)in Baoding Maternal and Child Health Hospital from May 2018 to May 2022 were retrospectively analyzed.According to the different ovulation induction protocols,they were divided into group A(n=76),group B(n=73)and group C(n=65).Group A adopted short protocol,group B adopted antagonist protocol,and group C adopted micro-stimulation protocol.The hormones levels and endometrial thickness on the trigger day,the number of days and dosage of gonadotropin(Gn),treatment status and pregnancy outcomes were compared among the three groups.Results On the trigger day,the luteinizing hormone(LH)in group C was higher than that in group A and group B,and the endometrial thickness was thinner than that in group A and group B.The estradiol(E2)in group A was higher than that in group B and group C(P＜0.05),but there were no statistical differences in the LH and endometrial thickness between group A and group B and the E2 between group B and group C(P＞0.05).The number of days and dosage of Gn were manifested as group A＞group B＞group C(P＜0.05).The average number of oocytes retrieved,the average number of available embryos and the average number of high-quality embryos were less in group C than those in group A and group B(P＜0.05),but no statistical differences were shown between group A and group B(P＞0.05).The clinical pregnancy rate in group B was higher compared to those in group A and group C(P＜0.05),but there was no statistical significance between group A and group C(P＞0.05).Conclusions The use of different ovulation induction protocols during IVF-ET assisted pregnancy in patients with POR will affect the pregnancy outcomes,and antagonist protocol has more advantages than the short protocol and micro-stimulation protocol.
万方数据
维普
