Clinical value of combined detection of peripheral blood neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,serum carcinoembryonic antigen and squamous cell carcinoma antigen in predicting the recurrence and metastasis of cervical cancer after che
Objective To explore the clinical value of combined detection of peripheral blood neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),serum carcinoembryonic antigen(CEA)and serum squamous cell carcinoma antigen(SCCA)in predicting the recurrence and metastasis of cervical cancer after chemoradiotherapy.Methods A total of 148 patients with cervical cancer admitted to Zhejiang Jinhua Guangfu Oncology Hospital from January 2019 to December 2022 were selected as the study objects,and they all received chemoradiotherapy.According to the conditions of recurrence and metastasis,the patients were classified into recurrence-metastasis group and non-recurrence-metastasis group.The NLR,PLR,CEA and SCCA levels were compared between the two groups.The relationship between NLR,PLR,CEA and SCCA levels and the clinicopathological features in the recurrence-metastasis group was analyzed.Multivariate Cox regression analysis was applied to analyze the influencing factors of the recurrence and metastasis of cervical cancer after chemoradiotherapy.The predictive ralue of NLR,PLR,CEA and SCCA alone and in combination on the recurrence and metastasis of cervical cancer after chemoradiotherapy was analyzed by receiver operating characteristic(ROC)curve.Results The incidence rate of recurrence and metastasis in 148 patients with cervical cancer was 27.70％(41/148).The levels of NLR,PLR,CEA and SCCA in the recurrence-metastasis group were all higher than those in the non-recurrence-metastasis group(P＜0.05).The levels of NLR,PLR,CEA and SCCA in the recurrence-metastasis group were correlated with federation international of gynecology and obstetrics(FIGO)staging and Karnofsky performance status(KPS)score(P＜0.05).The FIGO staging,KPS score,NLR,PLR,CEA and SCCA were independent risk factors influencing the recurrence and metastasis of patients(P＜0.05).The prediction efficiency of the combined detection of NLR,PLR,CEA and SCCA was higher than that of single detection(P＜0.05).Conclusions The risk of recurrence and metastasis of cervical cancer after concurrent chemoradiotherapy is related to multiple factors.The higher NLR,PLR,CEA and SCCA levels of patients,the greater the risk of recurrence and metastasis.The combined detection of the above indicators have higher predictive efficiency,and can predict the recurrence condition of cervical cancer more accurately.
Neutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioCarcinoembryonic antigenSquamous cell carcinoma antigenCervical cancer
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