The relationship between the changes in serum levels of CC-chemokine ligand 18 and human kallikrein 10 and the malignant biological behavior of ovarian cancer
Objective To investigate the changes in serum levels of CC-chemokine ligand 18(CCL18)and human kallikrein 10(HK10)in ovarian cancer and their relationship with malignant biological behavior of the tumor.Methods A total of 100 ovarian cancer patients admitted to the Cangzhou Hospital of Integrated Traditional Chinese and Western of Hebei Province from January 2018 to April 2023 were selected as the study group.A total of 50 patients with benign ovarian tumors were selected as the control group,and 50 healthy volunteers were selected as the healthy group.The levels of serum CCL18 and HK10 in the three groups,the levels of serum CCL18 and HK10 in patients with different malignant biological behaviors in the study group,and the changes in serum CCL18 and HK10 levels before and after chemotherapy for 3 and 6 cycles in patients with different chemotherapy sensitivity in the study group were compared.The relationship between the changes in serum CCL18 and HK10 levels before and after chemotherapy and chemotherapy sensitivity,as well as their predictive value for chemotherapy sensitivity were analyzed.Results The levels of serum CCL18 and HK10 in the study group were both higher than those in the control group and the healthy group(P＜0.05).Comparison of the levels of serum CCL18 and HK10 in patients with different international federation of gynecology and obstetrics(FIGO)stages,lymph node metastasis,and muscle invasion,as well as the levels of serum HK10 in patients with different degrees of differentiation in the study group showed statistically significant differences(P＜0.05).The CCL18 △1(△1 is the absolute value of the change between three cycles of chemotherapy and before chemotherapy)and HK10△1 of the insensitive patients in the study group were lower than those of the sensitive patients(P＜0.05).The area under the curve(AUC)of the combined detection of CCL18 △1 and HK10 △1 was significantly greater than that of a single index(P＜0.05).Conclusions The elevated levels of serum CCL18 and HK10 in ovarian cancer are closely related to the malignant biological behavior of the tumor,and their changes can assist in predicting the sensitivity of chemotherapy in clinical practice.The combined detection of the two has a high sensitivity for chemotherapy.
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