Analysis of the influencing factors of the positive margins and residual lesions after conization for high-grade squamous intraepithelial lesions of the cervix based on Lasso-Logistic regression analysis
Objective To explore the influencing factors of positive margins and residual lesions after conization for high-grade squamous intraepithelial lesions(HSIL)of the cervix based on Lasso-Logistic regression analysis.Methods A total of 160 patients with cervical HSIL who were treated in Hengshui People's Hospital from July 2021 to January 2022 were selected as the research objects,all of whom underwent cervical conization.Patients were divided into a study group(n=39)and a control group(n=121)based on the presence or absence of positive resection margins and residual lesions after conization.Patients with positive resection margins or residual lesions after surgery were included in the study group,while patients with negative resection margins after surgery were included in the control group.The clinical data of the two groups were compared,and Lasso-Logistic regression analysis was used to analyze the influencing factors of positive margins and residual lesions in patients with cervical HSIL after conization.Results The positive margin rate of cervical HSIL patients after conization was 24.38％,and the residual lesion rate in patients with positive margins was 48.72％.Highrisk-human papilloma virus(HR-HPV),lesion grade,involved quadrant,involved gland,type of transformation zone,shape of electrotomy ring,depth of conization,width of conization,volume of conization,and contact bleeding were all independent influencing factors of the positive margins and residual lesions after cervical HSIL conization(P＜0.05).Conclusions HR-HPV,lesion grade,involved quadrant,involved gland,type of transformation zone,shape of electrotomy ring,depth of conization,width of conization,volume of conization,and contact bleeding are all influencing factors of the positive margins and residual lesions after conization in patients with cervical HSIL.Clinical treatment should be optimized based on the relevant factors to reduce the positive margins and residual lesion rates.
CervixHigh-grade squamous intraepithelial lesionConization of cervixPositive marginResidual lesion
万方数据
维普
