Expression and clinical significance of transient receptor potential melastatin 7 and B cell translocation gene 2 in cervical cancer tissue
Objective To investigate the expression and clinical significance of transient receptor potential melastatin 7(TRPM7)and B cell translocation gene 2(BTG2)in cervical cancer tissue.Methods A total of 110 cervical cancer patients admitted to Shijiazhuang Maternal and Child Health Hospital from May 2018 to May 2020 were selected as the research objects,and their tumor and adjacent tissues were taken during surgery.They were grouped into a good prognosis group and a poor prognosis group according to the follow-up condition.Immunohistochemical method was applied to detect the expression of TRPM7 and BTG2 proteins in adjacent and tumor tissues.The relationship between TRPM7 and BTG2 protein expression levels and the clinicopathological features of patients was analyzed.TRPM7 and BTG2 protein expression in tumor tissues of the poor prognosis group and the good prognosis group were compared.Cox regression was applied to analyze the influencing factors for the prognosis of cervical cancer patients.Kaplan-Meier curve was used to analyze the relationship between TRPM7 and BTG2 levels and the prognosis of cervical cancer patients.Results Compared with adjacent tissues,the expression level of TRPM7 protein in cervical cancer tumor tissue increased and the expression level of BTG2 protein reduced(P＜0.05).The expression levels of TRPM7 and BTG2 proteins were related to tumor differentiation,lymph node metastasis,and malignant tumors international clinicopathology tumor node metastasis(TNM)classification(P＜0.05).Compared with the good prognosis group,the expression level of TRPM7 protein in the tumor tissue of poor prognosis group increased,while the expression level of BTG2 protein decreased(P＜0.05).TRPM7,TNM stage(stage Ⅲ),low differentiation of tumor and lymph node metastasis were risk factors for the prognosis of cervical cancer patients(P＜0.05),and BTG2 is a protective factor for the prognosis of patients with cervical cancer(P＜0.05).The 3-year survival rate of patients in the high TRPM7 expression group was lower than that in the low TRPM7 expression group(P＜0.05).The 3-year survival rate of patients in the high BTG2 expression group was higher than that in the low BTG2 expression group(P＜0.05).Conclusions TRPM7 protein expression is up-regulated and BTG2 protein expression is down-regulated in the tumor tissues of cervical cancer patients,and they are both related to the prognosis of cervical cancer patients.
Transient receptor potential melastatin 7B cell translocation gene 2Cervical cancer
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