中国性科学2024，Vol.33Issue(12) ：45-49.DOI:10.3969/j.issn.1672-1993.2024.12.011

胚胎培养液mtDNA拷贝数与体外受精-胚胎移植治疗中胚胎质量相关性的Meta分析

Meta-analysis of the relationship between copy number of mitochondrial DNA in embryo culture medium and embryo quality in in vitro fertilization-embryo transfer treatment

高辉 郑群 余柯达 师帅
中国性科学2024，Vol.33Issue(12) ：45-49.DOI:10.3969/j.issn.1672-1993.2024.12.011
✕
  • 维普
  • 万方数据

胚胎培养液mtDNA拷贝数与体外受精-胚胎移植治疗中胚胎质量相关性的Meta分析

Meta-analysis of the relationship between copy number of mitochondrial DNA in embryo culture medium and embryo quality in in vitro fertilization-embryo transfer treatment

高辉 1郑群 1余柯达 1师帅1
扫码查看

作者信息

  • 1. 金华市人民医院生殖医学中心,浙江金华 321000
  • 折叠

摘要

目的 通过中英文文献系统评价胚胎培养液中线粒体DNA(mtDNA)拷贝数与体外受精-胚胎移植(IVF-ET)治疗中胚胎质量的相关性.方法 检索中国知网、万方、维普等中文数据库和PubMed、Embase、the Cochrane Library等英文数据库中与胚胎培养液中mtDNA拷贝数和IVF-ET治疗中胚胎质量相关的临床研究,检索时限为建库至2023年12月.采用Cochrane系统评价文献质量,并提取文献中相关数据应用RevMan5.3软件进行分析.结果 本研究共纳入15篇文献(8篇中文文献,7篇英文文献),包括3 542例患者.Meta分析结果显示,接受IVF-ET治疗患者mtDNA拷贝数与受精率、优质胚胎率、胚胎评分呈强正相关性(r=0.726、0.668、0.709,P＜0.000 01),与卵裂率呈弱正相关性(r=0.280,P=0.030).发表偏倚分析结果显示,mtDNA拷贝数与受精率、优质胚胎率、优质胚胎率、胚胎评分相关性文献的漏斗图分布点基本对称,无发表偏倚.结论 胚胎培养液中mtDNA拷贝数与IVF-ET治疗中胚胎质量有一定相关性,临床可通过检测胚胎培养液中mtDNA拷贝数辅助评估胚胎质量,为临床IVF-ET治疗过程控制提供评定依据.

Abstract

Objective To evaluate the correlation between the copy number of mitochondrial DNA(mtDNA)in embryo culture medium and embryo quality in in vitro fertilization-embryo transfer(IVF-ET)treatment through Meta-analysis of Chinese and English literatures systems.Methods The Chinese databases of CNKI,Wanfang,VIP and the English databases of PubMed,Embase and the Cochrane Library were searched for clinical studies on the relationship between the copy number of mtDNA in embryo culture medium and embryo quality in IVF-ET treatment.The search period was from the establishment of the databases to November 2023.The literature quality was evaluated by Cochrane system.The relevant data in the literature were extracted and analyzed by RevMan5.3 software.Results A total of 15 papers(8 Chinese papers and 7 English papers)were included in this study,including 3,542 patients.The results of Meta-analysis showed that the copy number of mtDNA in patients receiving IVF-ET treatment was highly positively correlated with the fertilization rate,high quality embryo rate and embryo score(r=0.726,0.668,0.709;P＜0.000,01),and weakly positively correlated with the cleavage rate(r=0.280,P＜0.030).The results of publication bias analysis showed that the funnel chart distribution of the correlation between the copy number of mtDNA and the fertilization rate,high quality embryo rate,high quality embryo rate and embryo score was basically symmetrical with no publication bias.Conclusions There is a certain correlation between the copy number of mtDNA in embryo culture medium and the embryo quality in IVF-ET treatment.Clinical evaluation of embryo quality can be assisted by detecting the copy number of mtDNA in embryo culture medium,which provides an evaluation basis for clinical process control of IVF-ET treatment.

关键词

体外受精-胚胎移植/胚胎培养液/线粒体DNA/胚胎质量/Meta分析

Key words

In vitro fertilization-embryo transfer/Embryo culture medium/Mitochondrial DNA/Embryo quality/Meta-analysis

引用本文复制引用

出版年

2024
中国性科学
中国性学会

中国性科学

CSTPCD
影响因子：1.394
ISSN：1672-1993
段落导航相关论文