Predictive value of retinol-binding protein 4 on the treatment effect of progesterone therapy in patients with endometrial hyperplasia based on decision curve and dose-response analysis
Objective To analyze the predictive value of retinol-binding protein 4(RBP4)on treatment effect of progesterone therapy in patients with endometrial hyperplasia based on decision curve and dose-response analysis.Methods A total of 133 patients of endometrial hyperplasia admitted to Northwest Women's and Children's Hospital from March 2020 to February 2023 were retrospectively selected,and were divided into effective group(n=114)and ineffective group(n=19)according to the treatment results of the patients.The levels of progesterone,estradiol,luteinizing hormone,follicle stimulating hormone,and RBP4 in patients were compared.Logistic analysis was used to analyze factors influencing the treatment effect of progesterone therapy.Decision curve and dose-response analysis of RBP4 were used to analyze predicting value of RBP4 on treatment effect of progesterone treatment in patients with endometrial hyperplasia Results Compared with the ineffective group,the effective group had significantly decreased levels of progesterone,follicle stimulating hormone,estradiol,luteinizing hormone,and RBP4(P＜0.01).Logistic regression analysis showed that progesterone,estradiol,luteinizing hormone,follicle stimulating hormone,and RBP4 were all risk factors for progesterone treatment effect in patients with endometrial hyperplasia(P＜0.05).According to decision curve analysis,RBP4 had high value in predicting the treatment effect of progesterone therapy in patients with endometrial hyperplasia when the threshold was at 0.4-0.6.The correlation strength between RBP4 and the treatment effect of progesterone therapy in patients with endometrial hyperplasia showed a linear dose-response relationship(P＜0.05).Conclusions The detection of RBP4 levels has certain predictive value for the treatment effect of progesterone in patients with endometrial hyperplasia,and there is a linear dose-response relationship between it and the patient's treatment effect.
Decision curveDose-responseRetinol-binding protein 4Endometrial hyperplasiaProgesteroneTreatment effect
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