The diagnosis and treatment process of a case of hypogonadotropic hypogonadism(HH)patient was analyzed and literatures were reviewed,to explore the diagnosis,treatment and ovulation induction protocol of HH.37-year-old patient with primary amenorrhea and underdeveloped secondary sexual characteristics was treated with single estrogen supplementation therapy for over 2 months after a definite diagnosis of HH,and then received the sequential treatment of estrogen and progestogen for 2 cycles to promote the development of uterus and secondary sexual characteristics.Human menopausal gonadotropin(hMG)was used for ovulation induction therapy.The second cycle of ovulation induction treatment resulted in successful pregnancy,and one male infant was delivered by caesarean section at 36+4 weeks.To manage elderly HH patients with primary amenorrhea and fertility requirements,the time for promoting sexual characteristics development can be shorten to six months.hMG ovulation induction therapy is required to adjust the dosage according to the condition of follicular development,and tapering plan may be more economical and effective.
关键词
低促性腺激素性性腺功能减退症/活产/原发性闭经/高龄
Key words
Hypogonadotropic hypogonadism/Live birth/Primary amenorrhea/Advanced age
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