Gene modification technology,represented by transgenesis and gene editing,can easily and rapidly modify the specific genes of animals to obtain heritable and improved traits.Genetic modification technology has been successfully applied to enhance meat production,improve meat quality,mitigate environmental pollution,and enhance disease resistance and stress tolerance in agricultural animals.As a difficult point of traditional selective breeding-disease resistance,the application of gene modification technology has greater advantages and application prospects.The use of gene modification strategies to express virus resistance genes or to knock out key genes controlling virus infection in hosts can confer animals with enhanced resistance to specific viruses,providing valuable new breeding materials to cultivate disease-resistant varieties.This paper reviews the current research progress on transgenic and gene editing technology in pig disease resistance breeding,and discusses the possible problems and solutions of transgenic and gene editing technology in translational applications,providing certain reference for research on pig disease resistance breeding in my country.