The main function of granulosa cells(GC)is to provide necessary growth factors,nutrients and metabolic intermediates for oocytes,and secrete estrogen necessary for normal reproductive function.Granulosa cell apoptosis affects the quality of oocytes,and then reduces the fertilization rate and pregnancy success rate of livestock and animals.Apoptosis ligand and receptor system are the main factors inducing granulosa cell apoptosis,which is the main cause of follicular atresia.Follicular atresia is not only the main cause of oocyte loss,but also a huge waste of genetic resources of female animals.A ligand can bind to a variety of receptors and enter the pathways of cell proliferation and apoptosis.Therefore,this paper reviews the apoptosis ligand and receptor system and its role in granulosa cells,in order to provide reference for livestock reproduction.
ApoptosisFollicular atresiaGranulosa cellsFarm animalApoptosis ligand and receptor systems
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