Advances in the Interaction Mechanism between Bacterial Extracellular Vesicles and Host
Bacterial extracellular vesicles(BEVs)are a type of nanoscale particles secreted by bacteria that can carry and transport various substances,playing important roles in the interaction between the mother bacteria and the host.Evidences have proved that BEVs can carry maternal bacterial derived antigen components to regulate immunity related pathways,achieving immune regulatory effects on the host,which providing new ideas for vaccine development.The intestinal BEVs can stimulate the production of mucin,enhance the intestinal barrier function,and inhibit intestinal inflammation,suggesting that these BEVs can serve as potential drugs for repairing the intestinal barrier function of patients with enteritis,as well as biomarkers for evaluating intestinal damage.In addition,BEVs can also regulate host metabolism through signaling pathways that regulate sugar and lipid metabolism.Conversely,the host can also affect the secretion of bacteria and their BEVs.This article reviews the composition of BEVs and their mechanisms of action in host immune regulation,intestinal barrier function,and metabolic processes,in order to provide reference for the clinical and production applications of BEVs.
国家科技期刊平台
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