首页|表观基因组学在猪遗传育种中的研究进展

表观基因组学在猪遗传育种中的研究进展

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生猪产业是我国畜牧业的支柱产业,我国的生猪养殖和猪肉消费量均占全球 50%以上,但种猪性能与国外差距较大。因此,培育拥有自主知识产权、性状优良的种猪是保障我国生猪养殖业可持续健康发展的关键,而揭示重要经济性状的遗传机制是猪遗传改良的基础。表观基因组学是在核苷酸序列不发生改变的情况下,研究基因组上的化学修饰和空间结构变化影响基因表达调控和功能的一门学科,近年来在猪遗传育种领域逐步得到广泛应用。表观基因组学在解释分子功能机制、挖掘功能靶点、探究进化过程方面有着突出优势,为研究猪复杂性状和环境适应的生物分子调控机制提供新思路。本文分析和总结了表观基因组学在猪遗传育种领域的研究现状和发展趋势,为阐明猪重要经济性状形成机制提供参考。
Advances in Epigenomics in Pig Genetic Breeding
The pig industry is the backbone of China's livestock industry,and China's pig breeding and pork consumption both account for more than 50%of the world,but the performance of breeding pigs has a large gap with foreign countries.Therefore,breeding breeding pigs with independent intellectual property rights and excellent traits is the key to ensure the sustainable and healthy development of China's pig breeding industry,and revealing the genetic mechanism of important economic traits is the basis for breed improvement.Epigenomics is a discipline that studies chemical modifications and spatial structural changes on the genome that affect the regulation of gene expression and function without changing the nucleotide sequence,and has been widely used in pig genetic breeding in recent years.Epigenomics has outstanding advantages in explaining molecular functional mechanisms,exploring functional targets and probing evolutionary processes,and provides new ideas for studying the biomolecular regulatory mechanisms of complex traits and environmental adaptations in pigs.This article summarizes the current status and trend of epigenomics research in pig genetic breeding,and provides a reference for elucidating the formation mechanism of important economic traits in pigs.

PigEpigenomicsRegulation of gene expressionGenetic breeding

简耀邦、李京津、李新云、齐晓龙、付亮亮

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华中农业大学动物科学技术学院,湖北武汉 430070

农业动物遗传育种与繁殖教育部重点实验室,湖北武汉 430070

表观基因组学 基因表达调控 遗传育种

湖北洪山实验室重大项目

2021hszd003

2024

中国畜牧杂志
中国畜牧兽医学会

中国畜牧杂志

CSTPCD北大核心
影响因子:0.704
ISSN:0258-7033
年,卷(期):2024.60(3)
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