Effects of Ellagic Acid on Growth Performance,Blood Biochemical Indices and Antioxidant Function of Piglets Infected with Porcine Epidemic Diarrhea Virus
The aim of this experiment was to investigate the effects of ellagic acid(EA)on growth performance,plasma biochemistry indices,and serum antioxidant function in piglets infected with porcine epidemic diarrhea virus(PEDV).Thirty healthy 7-day-old ternary crossbred(Duroc×Landrace×Yorkshire)piglets were divided into control group,PEDV group,and PEDV + EA group according to the principle of similar body weight,with 10 replicates per group and 1 pig per replicate.All piglets were normally fed liquid artificial milk every day.The experiment lasted for 11 d,of which the first 3 days were the adaptation period.Piglets in the PEDV + EA group were given EA with liquid artificial milk as the solvent at a dose of 20 mg/kg BW on d 4 ～ 10 (except day 8), while the other groups were given equal volume of liquid artificial milk. On d 8, piglets in the PEDV and PEDV + EA groups were given 1 mL of 1×106 TCID50 PEDV solution. Venous blood was collected in the morning of d 11, followed by slaughter and collecting tissue samples. The results showed as follows: Compared with the control group, PEDV infection decreased the average daily weight gain (ADG) (P<0.05), but increased the diarrhea index of piglets (P<0.05). In addition, PEDV infection increased blood urea nitrogen level (P<0.05), while decreased the alkaline phosphatase activity, the levels of phosphorus and high-density lipoprotein, as well as the activity of catalase and superoxide dismutase (SOD) in serum in piglets (P<0.05). Compared with the PEDV group, EA administration increased the plasma total-protein level and serum SOD activity (P<0.05), while decreased the plasma total bilirubin level (P<0.05). However, EA had no significant effect on ADG and diarrhea index of piglets. In conclusion, our results showed that EA improved protein synthesis and metabolism in piglets infected with PEDV, alleviated oxidative stress induced by PEDV challenge, and enhanced the health of liver to some extent.
Ellagic acidPorcine epidemic diarrhea virusPigletsGrowth performancePlasma biochemistryAntioxidant function
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