蜂胶中多酚化合物对奶牛乳腺炎的缓解作用及机制研究进展
Recent Progress on Effects and Mechanisms of Propolis Polyphenols on Mastitis in Dairy Cows
祝梅斐 1李婧妍 1王炳 2李珊珊 1胡福良1
作者信息
- 1. 浙江大学动物科学学院,浙江杭州 310058;浙江省蚕蜂资源与创新研究重点实验室,浙江杭州 310058
- 2. 中国农业大学动物科学技术学院,动物营养国家重点实验室,北京 100193
- 折叠
摘要
奶牛乳腺炎主要是由病原体感染等多方面因素引起的炎症性疾病,导致泌乳量和乳品质大幅下降,给奶牛养殖业和乳制品行业带来严重经济损失.乳腺炎可能受NF-κB、MAPK、JAK-STAT、PI3K-AKT-mTOR和Nrf2-ARE等信号通路调控.蜂胶是由蜜蜂工蜂采集植物树脂,并加入其蜡腺、上颚腺等分泌物加工形成,其主要活性成分是多酚化合物,可通过杀灭奶牛乳腺炎病原、降低炎症反应、作为疫苗佐剂等方式有效缓解奶牛乳腺炎.本文概述了乳腺炎的作用机制,总结了蜂胶提取物及多酚缓解奶牛乳腺炎的作用效果,为更好地将蜂胶中多酚化合物应用于奶牛乳腺炎防治提供理论依据.
Abstract
Bovine mastitis is an inflammatory disease which caused by various factors including pathogenic infections.The severe mastitis could result in a significant reduction in milk production and quality,further leading to serious economic losses in the dairy industry.Mastitis may be regulated by some signaling pathways such as NF-κB,MAPK,JAK-STAT,PI3K-AKT-mTOR and Nrf2-ARE.Propolis is gathered from plant resin and mixed with the secretion of the worker bees.Propolis riching in polyphenolic compounds has been proven to play an effective role in the prevention of bovine mastitis by killing mastitis pathogens,alleviating inflammation,and acting as a vaccine adjuvant.This article outlines the mechanism of mastitis,and summarizes the effects of propolis extracts and polyphenols on relieving bovine mastitis,which will provide a theoretical basis for better application of propolis polyphenols in the prevention of mastitis in dairy cows.
关键词
奶牛乳腺炎/蜂胶/多酚/信号通路Key words
Bovine mastitis/Propolis/Polyphenols/Signaling pathway引用本文复制引用
基金项目
国家自然科学基金面上项目(31972588)
现代农业产业技术体系建设项目(CARS-44)
出版年
2024
国家科技期刊平台
NSTL
万方数据