细胞程序性死亡调控动物卵泡闭锁的分子机制
Molecular Mechanisms of Programmed Cell Death Regulating Follicular Atresia in Animals
张钰 1刘雪明 1刘萍萍 1甘和攀 1曹成鹏 1陈国宏 1徐琪1
作者信息
- 1. 扬州大学动物科学与技术学院,江苏扬州 225009
- 折叠
摘要
卵泡闭锁是一个受高度受调控的复杂过程,与颗粒细胞的程序性死亡密切相关.细胞凋亡、自噬、铁死亡、坏死性凋亡和焦亡等独立或相互作用参与调控卵泡闭锁和影响卵巢功能,本文综述了这 5 种细胞程序性死亡方式调控动物卵泡闭锁的分子机制及相关影响因素,以期为减少颗粒细胞程序性死亡诱导的卵泡闭锁、提高畜禽的繁殖性能提供参考.
Abstract
Follicular atresia is an intricately regulated phenomenon that is closely associated with the programmed cell death of granulosa cells.Studies have revealed that apoptosis,autophagy,ferroptosis,necroptosis,and pyroptosis operate either independently or in conjunction with one another to govern follicular atresia and exert an impact on ovarian function.This study provides an overview of the molecular mechanisms and the associated factors underlying these five modes of programmed cell death in the regulation of animal follicular atresia,which can serve as a valuable reference for mitigating follicular atresia caused by programmed granulosa cell death and enhancing the reproductive outcomes of livestock and poultry.
关键词
卵泡闭锁/颗粒细胞/细胞程序性死亡Key words
Follicular atresia/Granulosa cell/Programmed cell death引用本文复制引用
基金项目
江苏省农业自主创新资金项目(CX223033)
大学生创新创业训练计划(XCX20230737)
出版年
2024
国家科技期刊平台
NSTL
万方数据