PARK7基因对氧化应激的调控研究进展
Research Progress on the Regulation of Park7 Geneon Oxidative Stress
樊庆灿 1王倩倩 2杨虎 1郑路程 2胡威1
作者信息
- 1. 宜春学院生命科学与资源环境学院,江西宜春 336000
- 2. 宜春学院生命科学与资源环境学院,江西宜春 336000;甘肃农业大学动物医学院,甘肃兰州 730000
- 折叠
摘要
在规模化养殖模式下,畜禽在生长过程中会不可避免地面对各种不利因素,导致体内产生氧化应激,严重影响其生长发育.畜禽体内存在多种抗氧化因子来应对氧化应激.其中,帕金森相关蛋白 7(Parkinson's Disease-Associated Protein 7,PARK7)基因是细胞氧化应激中重要的调控因子之一.PARK7 通过自身半胱氨酸的氧化水平感受氧化应激信号,并通过Nrf2、ERK1/2 和PI3K/Akt等途径促进抗氧化酶的生成,提高细胞的抗氧化能力,从而减轻氧化应激引起的损伤.本文对PARK7基因在氧化应激中的调控作用和通路进行综述,将有助于畜禽氧化应激的调节机制研究.
Abstract
Under the large-scale breeding mode,the livestock inevitably faces various adverse factors in the growth process,which leads to oxidative stress in the body and seriously affects their growth and development.There are a variety of antioxidant factors in livestock and poultry to cope with oxidative stress.Among them,Parkinson's disease associated protein 7(PARK7)gene is one of the important regulators in cellular oxidative stress.PARK7 senses oxidative stress signals through the oxidation level of its own cysteine,and promotes the generation of antioxidant enzymes through Nrf2,erk1/2,and pi3k/akt pathways to improve the antioxidant capacity of cells,thereby alleviating the damage caused by oxidative stress.
关键词
PARK7/DJ-1/氧化应激/Nrf2通路Key words
PARK7/DJ-1/Oxidative stress/Nrf2 pathway引用本文复制引用
基金项目
江西省教育厅科技项目(GJJ211628)
宜春学院校级大学生创新创业训练计划(第二批)(2021)(447)
出版年
2024
国家科技期刊平台
NSTL
万方数据