Research Progress on Breeding High-Yield Strains of Astaxanthin-Producting Phaffia rhodozyma
Astaxanthin(3,3'-dihydroxy-β,β'-carotene-4,4'-dione),a potent antioxidant,possesses diverse physiological functions including anti-inflammatory,anti-apoptotic,and anticancer properties.Natural astaxanthin is the preferred choice of consumers over chemically synthesized alternatives due to its superior biological activity,utilization efficiency,and enhanced safety profile.Phaffia rhodozyma,which can utilize a variety of carbon sources and has a short cultivation period,is an ideal natural source of astaxanthin.However,the limited yield of astaxanthin during production poses a hindrance to the widespread application of Phaffia rhodozyma in the industry.Consequently,this article provides an overview of the main methods in advancing the production of astaxanthin in Phaffia rhodozyma,encompassing mutagenesis breeding,optimization of culture conditions and growth media,and amelioration of the biological synthetic pathways.The aim is to lay a theoretical foundation for the application of Phaffia rhodozyma in the industry and the enhancement of astaxanthin production.
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