Research Progress on Molecular Mechanism of Microfilament Regulating Meiotic Maturation of Oocytes
Oocytes undergo two rounds of meiosis before fusing with sperm to form a zygote.In contrast to mitosis,both meiotic divisions are asymmetric and eventually generate one large volume of haploid oocytes with totipotent and two small volumes of doomed degenerate polar bodies.Actin filaments,as cytoskeletons in oocytes,are importantly linked to the biological events during division undergoing vesicle translocation,nuclear localization,spindle migration and anchoring,polar body extrusion,and chromosome segregation.This review uses mammals as a model to summarize the critical regulatory mechanisms and signaling pathways of actin in the meiotic maturation of oocytes,in order to provide a reference for further study on the regulation mechanism of oocyte maturation process.
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