Advances in the Mammalian Coat Color Candidate Gene c-KIT
The color of mammalian fur is mainly affected by the type and amount of melanin in the hair.The hypertrophi/stem cell growth factor receptor encoded by c-KIT gene(master/stem cell growth factor receptor,SCFR)is a tyrosine kinase transmembrane receptor associated with melanin biosynthesis.Mutations in c-KIT gene inhibit the receptor function of stem cell growth factors,resulting in the production,maturation,proliferation,differentiation and migration of melanocytes being affected.This article reviews the mechanisms of mammalian coat color formation and the main acting genes,the mechanism of c-KIT gene,and the influence of c-KIT gene on mammalian coat color,in order to provide a reference for in-depth study of the genetic mechanism of mammalian coat color and the selection and breeding of different coat colors.
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