The Mechanism of Protein Post-translational Modifications in PRRSV Infection
Porcine reproductive and respiratory syndrome virus(PRRSV)is a pathogen that seriously threatens the global pig industry,and its pathogenic mechanism has not been fully resolved.Post-translational modification of proteins is crucial to protein function,and can fine-regulate protein activity,stability and localization,thus affecting biological processes such as cell growth,differentiation and apoptosis.It triggers a series of complex biological processes during PRRSV infection.Among them,protein post-translational modification plays a crucial role in virus infection of the host cells,which can affect the host's recognition of the virus,and participate in the regulation of virus replication,proliferation and disease occurrence.This paper reviews the research progress on the mechanism of protein post-translational modifications such as phosphorylation,ubiquitination,glycosylation,palmitoylation,acetylation and lactation in PRRSV infection.It will provide a new idea for the study of pathogenesis of PRRSV,and provide a theoretical basis for the research and development of anti-PRRSV drugs.
国家科技期刊平台
NSTL
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