性激素调控大脑性别分化的研究进展
Advances in the Regulation of Sex Hormones on Brain Sexual Differentiation
陈晶 1李俊 2侯云鹏 3傅祥伟4
作者信息
- 1. 福建农林大学动物科学学院,福建福州 350002;中国农业大学动物科学技术学院,北京 100193
- 2. 中国农业大学动物科学技术学院,北京 100193;河北医科大学第一医院生殖中心,河北石家庄 050000
- 3. 中国农业大学生物学院,北京 100193
- 4. 中国农业大学动物科学技术学院,北京 100193
- 折叠
摘要
大脑结构的性别差异控制着不同性别的哺乳动物在成年时期表现出不同的性行为、社会行为以及内分泌调节等,雄性动物出生前后由睾丸产生的高水平雄激素是引起大脑性别分化的关键因素之一.然而,雄激素峰的具体产生和作用机制未完全阐明.近年来许多研究利用啮齿动物为模型,证明了雄激素峰上游被Kisspeptin所调控,下游通过转录水平、蛋白修饰以及免疫细胞等途径影响不同性别的大脑神经元和神经环路的发育.本文围绕雄激素峰上下游调控机制的研究进展进行综述,为家畜和人类逐年上升的繁殖疾病的可能机理研究提供参考.
Abstract
Mammalian species show different sexual behaviors,social behaviors and endocrine pathways between males and females at adult,which is caused by the sexual difference in brain.The dramatic elevation of plasma androgen during perinatal period has been demonstrated to be one of the key factors regulating brain sexual differentiation in many mammalian species.However,the specific mechanism of generation and action of perinatal androgen surges has not been fully elucidated.In recent years,Kisspeptin-mediated hypothalamus-pituitary-gonads(HPG)axis has been confirmed to stimulate the occurrence of perinatal androgen surges,while androgens cooperate with immune cells and epigenetic modifications in different regions of the brain to shape the morphology and function of the brain.In recent years,rodent models have been used to demonstrate that the upstream of androgen peak is regulated by Kisspeptin,and its downstream affects the development of brain neurons and neural circuits in different sexes through transcription level,protein modification,and immune cells.This review will focus on the research progress of the up-and downstream regulation mechanisms of androgen surge,so as to provide reference for the potential mechanisms of reproductive diseases whose incidence increased year by year in livestock and humans.
关键词
大脑性别分化/性激素/表观修饰/免疫细胞/KisspeptinKey words
Brain sexual differentiation/Sex hormones/Epigenetic modifications/Immune cells/Kisspeptin引用本文复制引用
基金项目
福建省中青年教师教育科研项目(JAT220070)
国家重点研发计划(2021YFD1200402)
出版年
2024
国家科技期刊平台
NSTL
万方数据