Advances in the Regulation of Skeletal Muscle Development by Major Signaling Pathways and Non-Coding RNAs
Skeletal muscle is an important component of the animal body,which not only directly affects the meat production performance and meat quality of economic animals,but also is closely related to body movement and metabolism.Skeletal muscle development is regulated by a variety of signals.WNT,NOTCH,BMP,TGF-β,and PI3K/AKT are the major signaling pathways involved in the regulation of skeletal muscle development,and non-coding RNAs(miRNAs,lncRNAs,and circRNAs)also play an important role in the regulation of skeletal muscle development.This paper summarizes the regulatory roles of major signaling pathways and non-coding RNAs in mammalian skeletal muscle development and their mechanisms,with a view to providing a reference for the study of regulatory networks in skeletal muscle development.