摘要
骨骼肌是动物躯体的重要组成部分,不仅直接影响经济动物的产肉性能和肉品质,还与机体运动、代谢密切相关.骨骼肌发育受多种信号共同调节,WNT、NOTCH、BMP、TGF-β、PI3K/AKT是参与调控骨骼肌发育的主要信号通路,非编码RNA(miRNA、lncRNA、circRNA)也在骨骼肌发育中发挥重要调控作用.本文总结了主要信号通路和非编码RNA在哺乳动物骨骼肌发育中的调控作用及其机制,以期为骨骼肌发育中调控网络研究提供参考.
Abstract
Skeletal muscle is an important component of the animal body,which not only directly affects the meat production performance and meat quality of economic animals,but also is closely related to body movement and metabolism.Skeletal muscle development is regulated by a variety of signals.WNT,NOTCH,BMP,TGF-β,and PI3K/AKT are the major signaling pathways involved in the regulation of skeletal muscle development,and non-coding RNAs(miRNAs,lncRNAs,and circRNAs)also play an important role in the regulation of skeletal muscle development.This paper summarizes the regulatory roles of major signaling pathways and non-coding RNAs in mammalian skeletal muscle development and their mechanisms,with a view to providing a reference for the study of regulatory networks in skeletal muscle development.
基金项目
国家自然科学基金(32102514)
广西自然科学基金(2020GXNSFBA297148)
大学生创新创业训练计划项目(S202210593350)
国家科技期刊平台
NSTL
万方数据