首页|X-ray excited Mn2+-doped persistent luminescence materials with biological window emission for in vivo bioimaging
X-ray excited Mn2+-doped persistent luminescence materials with biological window emission for in vivo bioimaging
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In recent years,persistent luminescence materials(PLMs)excited by X-rays and emitting in biological windows have received extensive attention in the field of high-sensitivity bioimaging.Transition metal Mn2+is an ideal emission center,but few studies focus on Mn2+-doped PLMs with X-ray excitation and biological window emission.Here,we report a Mn2+-doped PLM,LiYGeO4:Mn2+(LYGM),with excellent biological window persistent luminescence emission.After excitation by UV,LYGM produces a durable biological window of persistent luminescence emission at 660 nm for up to 20 h.More importantly,LYGM can be repeatedly excited by X-rays,resulting in long-term biological window persistent lumi-nescence emission.In addition,we obtain LYGM around 200 nm in diameter by ball milling and centrifugation and improve its biocompatibility by surface modification to apply it to in vivo imaging in mice.After LYGM are injected into mice through the tail vein,in situ excitation of X-rays can be achieved.After the persistent luminescence decays,LYGM can be re-excited for repeated imaging.Therefore,LYGM shows potential prospects for in vivo deep tissue and long-term bioimaging.
Persistent luminescenceX-rayBiological windowIn vivo imagingRare earths
State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou,350002,China
University of the Chinese Academy of Sciences,Beijing,100049,China
Xiamen Hospital of Traditional Chinese Medicine,Xiamen,361015,China
Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China,Fuzhou,350108,China
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National Natural Science Foundation of ChinaKey Research Program of the Chinese Academy of SciencesFujian Science & Technology Innovation Laboratory for Optoelectronic Information of ChinaXiamen Medical and Health Guidance Project,China
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