首页|One-step hydrothermal synthesis of Cit-NaYbF4∶Er3+nanocrystals with enhanced red upconversion emission for in vivo fluorescence molecular tomography

One-step hydrothermal synthesis of Cit-NaYbF4∶Er3+nanocrystals with enhanced red upconversion emission for in vivo fluorescence molecular tomography

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Fluorescence imaging techniques represent essential tools in in vitro,preclinical,and clinical studies.In this study,an improved one-step hydrothermal method to synthesize citric acid(CA)modified α-NaYbF4∶2％Er3+nanocrystals was proposed.The introduction of various doping ions into NaYbF4∶2％Er3+and the different valence states of the same ions affect both the crystal size and upconversion lumi-nescence.Therefore,we investigated the upconversion luminescence enhancement of NaYbF4∶2％Er3+by ion doping and find that the upconversion luminescence intensity of the upconversion nanoparticles(UCNPs)co-doped with 5 mol％Fe2+ions shows the greatest enhancement,especially for red emission at 654 nm.Furthermore,HeLa cells incubated with UCNPs allow for imaging with strong red upconversion emission detection.Confocal laser scanning microscope(CLSM)fluorescent images of HeLa cells indicate that NaYbF4∶2％Er/5％Fe2+leads to a clear outline and improves visualization of the cell morphology.In addition,the CA coated NaYbF4∶2％Er3+/5％Fe2+nanoparticles and NaYbF4∶2％Er3+/5％Fe2+show low cytotoxicity in HeLa cells.Organ imaging reveals the efficiency of these UCNPs to analyze the lungs,liver,and spleen.Together,these results indicate that the Cit-NaYbF4:2％Er3+/5％Fe2+UCNPs are efficient nanoprobes for fluorescence molecular tomography.

Hydrothermal methodFe2+ ion dopingTuning sizeNanoprobesFluorescence imagingRare earths

Xiaoli Luo、Qichen Chen、Hongbo Guo、Heng Zhang、Xiaowei He、Wu Zhao

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School of Mathematics and Computer Science,Ningxia Normal University,Guyuan,756099,China

School of Information Science and Technology,Northwest University,Xi'an,710127,China

Natural Science Basic Research Program of Shaanxi ProvinceKey Program for International science and Technology Cooperation Projects of Shaanxi ProvinceNational Key Research and Development Program of ChinaScientific Research Plan of Shannxi Provincial Education Department,ChinaNingxia Natural Fund

2021JZ-432018KWZ-082019YFC152090418JK07802023AAC03338

2024

10.1016/j.jre.2022.09.027

稀土学报(英文版)
中国稀土学会

稀土学报(英文版)

CSTPCDEI
影响因子：1.3
ISSN：1002-0721
年,卷(期)：2024.42(1)
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