首页|Rare earth fluorescent nanoprobes with minimal side effects enable tumor microenvironment activation for chemotherapy

Rare earth fluorescent nanoprobes with minimal side effects enable tumor microenvironment activation for chemotherapy

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Chemotherapy,the use of antitumor drugs to kill cancer cells,is currently one of the most effective treatments for cancer.However,serious toxic side effects caused by long-term drug accumulation can cause significant damage to the body,which limits the clinical application of antitumor drugs.In this study,a novel RENPs@DOX-Fe nanoprobe(NP)was constructed by coating the surface of rare earth nanomaterials(NaLuF4∶Yb,Er)with a complex formed by doxorubicin(DOX)and iron ion(Ⅲ).Due to the low toxicity of anthracycline-metal complexes,the damage to normal cells is reduced.The unique acidic microenvironment in tumor cells facilitates the decomposition and gradual release of DOX from the DOX-Fe complex.In addition,the DOX-Fe complex can convert near-infrared(NIR)light into heat en-ergy,which promotes the decomposition of the complex,further enhancing the release of DOX in the tumor environment.The change of ratio fluorescence of rare earth nanomaterials at 660 and 1550 nm after DOX release enables visual monitoring of drug release,which can potentially improve the chemotherapeutic effect.In vitro experiments established that RENPs@DOX-Fe NPs with NIR illumination had good therapeutic efficacy in tumors.This work provides new insights into designing tumor microenvironment-responsive nanoprobes for chemotherapy with minimal side effects.

Rare earth nanoprobesFluorescenceRatiometric imagingDOXChemotherapy

Tianqi Cao、Yuxin Liu、Qi Jia、Xiaolu Wang、Shouqiang Zhang、Jing Zhou

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Department of Chemistry,Capital Normal University,Beijing,100048,China

National Natural Science Foundation of ChinaBeijing Municipal Education Commission Outstanding Young Individual ProjectYouth Highlevel Talent Project of Capital Normal UniversityYanjing Young Scholar Program of Capital Normal University

92159103CIT&TCD20190408220530810024

2024

10.1016/j.jre.2022.11.005

稀土学报(英文版)
中国稀土学会

稀土学报(英文版)

CSTPCDEI
影响因子：1.3
ISSN：1002-0721
年,卷(期)：2024.42(2)
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