首页|Heterobimetallic lanthanide tetrahedral cages:Synthesis,design and application for potential multimodal imaging contrast agent
Heterobimetallic lanthanide tetrahedral cages:Synthesis,design and application for potential multimodal imaging contrast agent
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The construction and functionalization of lanthanide-organic cages have been a research hotspot in coordination chemistry.Benefiting from the unique luminescent and magnetic properties of lanthanide ions,the potential applications of lanthanide-organic cages in biological imaging applications are promising,but only a few corresponding explorations have been reported.Herein,we introduced a series of lanthanide tetrahedral cages,(EunGd4-nL4)(sol)8(n=0,1,2,3 and 4,where L=(4,4',4"-tris(4,4,4-trifluoro-1,3-dioxobutyl)-triphenylamine,and sol=dimethyl sulfoxide and methanol),with potential applications in biological imaging.Given the good luminescent and magnetic properties of Eu3+and Gd3+ions,Eu4L4 and Gd4L4 complexes show a high luminescence quantum yield of 29％in DMSO and large longitudinal relaxivity(r1)of 11.4(mmol/L)-1/s at 0.5 T in water containing 1 vol％DMSO,respectively.The heterobimetallic Eu-Gd complexes achieve a dual imaging mode by combining lumi-nescent and magnetic centers in one cage.When the Gd:Eu ratio increases from 1∶3 to 3∶1,the r1 values increases from 5.33 to 8.64(mmol/L)-1/s,higher than that of commercial contrast agent Gd-DOTA(3.23(mmol/L)-1/s).Owing to their low toxicity and good cell imaging ability toward ECA 109 cells,the self-assembled Eu-Gd heterobimetallic tetrahedral cages could be potential candidates for the multimodal imaging contrast agent.
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