Surface morphology and cell viability of samarium(Ⅲ)oxide/chromium(Ⅲ)oxide/graphene oxide/polycaprolactone targeting wound dressing

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外文摘要：Combinations of metal and lanthanide oxides have been done through casted films for potential medical applications.In this regard,samarium(Ⅲ)oxide/chromium(Ⅲ)oxide/graphene oxide(GO)/poly-caprolactone(PCL)based films nano-composites(NCs)were fabricated,pointing their utilization as a biological scaffold for wound dressing purposes.Also,samarium(Ⅲ)oxide and chromium(Ⅲ)oxide have been merged as promising optical constituents due to their unique optical behavior.The structural and compositional examination of the studied NCs was executed by X-ray diffraction(XRD),Raman,and field emission scanning electron microscopy(FESEM).The Sm2O3/Cr2O3/GO/PCL NC exhibits a surface with a lower roughness degree owing to the presence of GO.Cr2O3 shows size reduction upon GO insertion to reach 1.2 μm as the average grain size,whilst Sm2O3 records an average grain size of less than 1 μm.As well,the polymeric nano-compositions exhibit variation in contact angle values that hit 29.76°±3.52° for Sm2O3/PCL,and 48.62°±1.37° for Sm2O3/Cr2O3/GO/PCL as the second lowest contact angle.The optical behavior contributes to absorption edge relocation along the x-axis from 1.7 eV for pure PCL,to 2.65 eV for Sm2O3/Cr2O3/GO/PCL.Regarding biological responses,the cell exposed to 2.5 μg/mL of Sm2O3/Cr2O3/GO/PCL shows cell viability of 119.31％,while 5 μg/mL hits 99.6％.Additionally,the resulting cell attachment micrographs show layers of fibroblast tissue,besides the proliferation and growth of culti-vated cells.Thus,the Sm2O3/Cr2O3/GO/PCL scaffold provides 3D proliferation of fibroblast cells endorsing the wound healing process.

外文关键词：

Wound healingWound dressingPolycaprolactoneSm2O3Cr2O3Rare earths

作者：

Muteb H.Alshammari、Ahmed Onayzan Alshammari、Mohamed Tharwat Elabbasy、Rafat Zreiq、Faris Mohammed Albati、M.A.El-Morsy、A.A.Menazea

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作者单位：

Department of Health Informatics,College of Public Health and Health Informatics,University of Ha'il,Ha'il,Saudi Arabia

Department of Surgery,College of Medicine,University of Ha'il,Ha'il,Saudi Arabia

Department of Public Health,College of Public Health and Health Informatics,Ha'il University,Ha'il,2440,Saudi Arabia

Food Control Department,Faculty of Veterinary Medicine,Zagazig University,Zagazig,44519,Egypt

Applied Science Research Center,Applied Science Private University,Amman,541350,Jordan

College of Shariah and Law,Ha'il University,Ha'il,2440,Saudi Arabia

College of Science and Humanities in Al-Kharj,Physics Department,Plasma Technology and Material Science Unit,Prince Sattam Bin Abdulaziz University,Al-kharj,11942,Saudi Arabia

Physics Department,Faculty of Science,University of Damietta,New Damietta,34517,Egypt

Spectroscopy Department,Physics Research Institute,National Research Centre,Dokki,12622,Giza,Egypt

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基金：

Scientific Research Deanship at University of Ha'il,Saudi Arabia through project number RG-21169

项目编号：

出版年：

2024

DOI：

10.1016/j.jre.2023.04.010

稀土学报(英文版)

中国稀土学会

稀土学报(英文版)

CSTPCDEI

影响因子：1.3

ISSN：1002-0721

年,卷(期)：2024.42(3)

参考文献量49