首页|Lanthanum promoting bone formation by regulating osteogenesis,osteoclastogenesis and angiogenesis

Lanthanum promoting bone formation by regulating osteogenesis,osteoclastogenesis and angiogenesis

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
With lanthanum(La)in agriculture,medicine,and the chemical industry,La shows accumulation in the body,especially in the bone,because of its similar structure to calcium.Moreover,La has a direct role in bone formation regulating osteoblasts and osteoclasts.Nevertheless,bone formation is complex under the regulation of osteogenesis,osteoclastogenesis,and angiogenesis in the bone microenvironment.It is difficult to comprehensively understand the regulation of bone homeostasis from a single kind of cell.Herein,some bone microenvironment-related cells and mouse calvaria culture models were used to study the regulatory effect of La-based compound-lanthanum nitrate(La(NO3)3)on bone formation.La(NO3)3 has good biological safety,and the osteogenic differentiation is significantly increased under La(NO3)3 treatment for bone marrow mesenchymal stem cells(BMMSC).In contrast,the differentiation,maturation,and bone erosion ability of osteoclasts are significantly decreased.Meanwhile,the angio-genesis ability of human umbilical vein endothelial cells(HUVEC)is significantly promoted when treated with La(NO3)3.Furthermore,bone metabolism and angiogenesis are improved under La(NO3)3 treatment in the calvaria ex vivo culture model and BMMSC-HUVEC co-culture system.These results suggest that La has the beneficial effect of promoting bone metabolism and improving bone formation in the bone microenvironment.

LanthanumBone microenvironmentOsteogenic differentiationAngiogenesisRare earths

Dandan Zou、Runlian Lin、Yu Han、Juan Jia、Guoqiang Zhou、Haisong Zhang、Kun Ge

展开 >

Hebei Key Laboratory of Chronic Kidney Diseases and Bone Metabolism,Affiliated Hospital of Hebei University,Baoding,071000,China

Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education,Key Laboratory of Chemical Biology of Hebei Province,College of Chemistry and Environmental Science,Hebei University,Baoding,071002,China

National Natural Science Foundation of ChinaNatural Science Foundation of Hebei ProvinceNatural Science Foundation of Hebei ProvinceHebei Province"Three Three Three Talents Program"Government Guided Local Science and Technology Fundations of Hebei ProvincePriority Strategy Project of the Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education

21807023B2019201449H2019201466A202003001216Z2403Gts2020003

2024

10.1016/j.jre.2023.01.019

稀土学报(英文版)
中国稀土学会

稀土学报(英文版)

CSTPCDEI
影响因子：1.3
ISSN：1002-0721
年,卷(期)：2024.42(3)
  • 41